The Commission is actively involved in sharing expertise and technology from all over the world and is implementing various programmes and projects in collaboration with its member countries, as well as international organizations/agencies. The size & scope of the programmes and projects varies from national and regional to international levels. These come from various cross-cutting themes that range from information & communications technologies, biotechnology, renewable energy technologies, provision of healthcare and education to capacity building in frontiers of sciences and technologies. COMSATS has working relations with the following international organizations:

• Abdus Salam International Centre for Theoretical Physics (ICTP);
• Alliance Francaise;
• Asian and Pacific Centre for Transfer of Technology (APCTT);
• Centre for Science and Technology of the Non-Aligned and Other Developing Countries (NAM S&T Centre);
• Chinese Academy of Sciences (CAS);
• Consortium on Science , Technology and Innovation for the South (COSTIS);
• Islamic Educational, Scientific and Cultural Organization (ISESCO);
• International Centre for Genetic Engineering and Biotechnology (ICGEB);
• International Development Research Centre (IDRC);
  
• International Centre for Integrated Mountain Development (ICIMOD);
  
• OIC Standing Committee on Scientific and Technological Cooperation (COMSTECH);
  
• South Centre;
  
• Sudan Academy of Sciences (SAS);
  
• The Academy of Sciences for the Developing World (TWAS);
  
• United Nations Industrial Development Organization (UNIDO);
  
• United Nations Educational, Scientific and Cultural Organization (UNESCO).